Susquehanna Depot is a borough in Susquehanna County, Pennsylvania. It is located along the Susquehanna River and surrounded by forest. The borough is often known as simply Susquehanna.

According to the United States Census Bureau of 2000, Susquehanna Depot is home to more than 1,650 residents. The borough has a total area of 0.7 square miles with a high population density of over 2,000 people per square mile.

The racial composition of Susquehanna Depot is 98.34% White, 0.12% African American, 0.95% Asian, and 0.59% from two or more races. Hispanic or Latino of any race are 1.24% of the population.

Susquehanna Depot has more than 600 households. The median income for a household in the borough is $27,328, and the median income for a family is $31,522.